2 The technology has since advanced, and it was a Canadian neurosurgeon who helped demonstrate both the efficacy and cost-effectiveness of spinal cord stimulation in chronic pain treatment. 2, 3, 5 It is based on the principle of electrically stimulating the dorsal column of the spinal cord, to mask pain signals. Neuromodulation, defined as the alteration of nerve activity through targeted stimulus delivery, was first introduced in 1967. When conventional therapies produce unacceptable adverse effects or do not provide sufficient pain relief, spinal cord stimulation (neuromodulation) may offer a rescue option, either alone or in conjunction with other modalities. 1, 2 Consequently, alternatives - including cognitive behavioural therapy, physical rehabilitation, non-opiate pharmacology and integrative therapies - have been developed. 1 Although opioids have been the mainstay of treatment, they have lost favourability owing to crises of addiction, abuse, tolerance and dependence. Increased awareness of and access to spinal cord stimulation therapy may allow more Canadians to benefit from relief of intractable chronic pain and may reduce opioid consumption.Ĭhronic pain affects 1 in 5 Canadians and is associated with considerable socioeconomic burden. Newer spinal cord stimulation technologies are expanding clinical indications such as visceral and ischemic pain, with potential for further improved efficacy. Spinal cord stimulation is safe, efficacious and cost-effective in chronic pain management of neuropathic pain conditions, including failed back surgery syndrome, chronic regional pain syndrome and chronic peripheral neuropathies. Spinal cord stimulation masks pain signals through a transcutaneous implantable electric pulse generator.
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I’ve known Alex for probably 10 years at this point, so I was on at the very early stages when it was just a prototype and he was still coming up with the ideas in his head. In that time, I’ve really grown as a musician and as a composer. This has been an interesting one because it was on and off in production for close to seven years. Outer Wilds is a very unique game with a fittingly interesting soundtrack, so how did working on it compare to your experience with previous projects? 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But, according to a Washington Post editorial: ‘In the first three quarters of 1998 nine times as many were exported as during the previous seven years.’” A supercomputer can simulate a nuclear test and is thus crucial to the development of nuclear warheads. “Supercomputers underpin the technology of nuclear and missile warfare, and not only for firing and controlling the missiles. “One of the key technological breaks China received, without having to spy to get it, was the deliverance of supercomputers once banned from export for security reasons,” writes Horowitz. President Clinton also lifted security controls, allowing thieves to access other vital military technologies, while disarming his own side and opposing needed defenses. 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